Comedy in San Diego on Wednesday, October 21, 2026

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3 shows across 3 venues in San Diego County on Wednesday, October 21, 2026. Updated nightly from venue calendars and ticketing sites.

Evening 1

8:00 PM
JR De Guzman & Friends | Wed 8PM
Comedy Store - La Jolla · San Diego
Comedian JR De Guzman hosts a Wednesday night show with friends at The Comedy Store La Jolla, starting at 8PM.
Tickets & details

On view · through Fri, Feb 26
National Comedy Theatre Improv Show
National Comedy Theatre · Other / unknown
An ongoing improv comedy show at the National Comedy Theatre in San Diego. Performances run regularly through early 2027.
Tickets & details
On view · through Tue, Dec 1
National Comedy Theatre Improv Show
Venue not listed · San Diego
The National Comedy Theatre hosts live improv comedy shows on an ongoing basis through early December 2026. This is a recurring series with performances multiple times per week.
Tickets & details